HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Grace Chung Selected Research

N- (4- ((3- (2- amino- 4- pyrimidinyl)- 2- pyridinyl)oxy)phenyl)- 4- (4- methyl- 2- thienyl)- 1- phthalazinamine

7/2015Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.
11/2014AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues.
11/2013AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models.
12/2010Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


Grace Chung Research Topics

Disease

10Neoplasms (Cancer)
01/2024 - 12/2002
3Breast Neoplasms (Breast Cancer)
11/2014 - 12/2002
2Ulcerative Colitis
04/2024 - 01/2023
2Obesity
12/2022 - 03/2022
1HIV Infections (HIV Infection)
01/2023
1Type 2 Diabetes Mellitus (MODY)
12/2022
1Hypertension (High Blood Pressure)
12/2022
1Cognitive Dysfunction
12/2022
1Hearing Loss (Hearing Impairment)
12/2022
1Dementia (Dementias)
12/2022
1Body Weight (Weight, Body)
03/2022
1Maternal Obesity
03/2022
1Gestational Diabetes (Gestational Diabetes Mellitus)
03/2022
1Opioid-Related Disorders (Opiate Addiction)
01/2021
1Disease Progression
01/2021
1Persistent Infection
01/2017
1Infections
01/2016
1Triple Negative Breast Neoplasms
11/2013
1Polyploidy
11/2013
1Ventricular Remodeling
04/2007
1Febrile Seizures (Febrile Seizure)
04/2006

Drug/Important Bio-Agent (IBA)

4N- (4- ((3- (2- amino- 4- pyrimidinyl)- 2- pyridinyl)oxy)phenyl)- 4- (4- methyl- 2- thienyl)- 1- phthalazinamineIBA
07/2015 - 12/2010
4Aurora KinasesIBA
07/2015 - 09/2010
4Histones (Histone)IBA
11/2014 - 09/2010
3Proteins (Proteins, Gene)FDA Link
01/2024 - 01/2017
2vedolizumabIBA
04/2024 - 01/2023
2KinesinsIBA
12/2023 - 01/2022
2Phosphotransferases (Kinase)IBA
11/2014 - 12/2002
2Taxoids (Taxanes)IBA
11/2013 - 12/2010
1Cell Adhesion Molecule-1IBA
04/2024
1Antimitotic AgentsIBA
01/2024
1Nucleic AcidsIBA
01/2023
1ApolipoproteinsIBA
12/2022
1Apolipoprotein E4IBA
12/2022
1Glucose (Dextrose)FDA LinkGeneric
03/2022
1Insulin (Novolin)FDA Link
03/2022
1Opioid Analgesics (Opioids)IBA
01/2021
1VaccinesIBA
01/2021
1Neutralizing AntibodiesIBA
01/2016
1Bromodeoxyuridine (BrdU)IBA
11/2014
1Oxygen (Dioxygen)IBA
11/2014
1Docetaxel (Taxotere)FDA Link
11/2013
1ixabepilone (BMS 247550)FDA Link
11/2013
1Pemetrexed (MTA)FDA Link
11/2013
1Serine (L-Serine)FDA Link
09/2010
1Matrix Metalloproteinases (MMPs)IBA
04/2007
1ConvulsantsIBA
04/2006
1Estrogen ReceptorsIBA
12/2002
1CyclinsIBA
12/2002

Therapy/Procedure

3Therapeutics
04/2024 - 12/2010
3Oral Administration
11/2014 - 09/2010
1Lasers (Laser)
11/2014